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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Emodin, Cytarabine
Phytochemical Name Emodin (PubChem CID: 3220 )
Anticancer drug Name Cytarabine (PubChem CID: 6253 )
Structure of
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Combination Pair ID: 729
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Pair Name Emodin, Cytarabine
Disease Info [ICD-11: 2A60.Z] Acute myeloid leukemia Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Phosphorylation AKT1 hsa207
Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Down-regulation Expression BID hsa637
Up-regulation Cleavage CASP3 hsa836
Down-regulation Phosphorylation MAPK1 hsa5594
Down-regulation Phosphorylation MAPK3 hsa5595
Down-regulation Phosphorylation MTOR hsa2475
Down-regulation Phosphorylation RPS6KB1 hsa6198
In Vitro Model HL-60 Adult acute myeloid leukemia Homo sapiens (Human) CVCL_0002
ARAC-8C Childhood T acute lymphoblastic leukemia Homo sapiens (Human) CVCL_GZ09
Jurkat Childhood T acute lymphoblastic leukemia Homo sapiens (Human) CVCL_0065
MOLT-4 Adult T acute lymphoblastic leukemia Homo sapiens (Human) CVCL_0013
CA46 Burkitt lymphoma Homo sapiens (Human) CVCL_1101
In Vivo Model Around 1.5×10⁷ HL-60/H3 cells were subcutaneously injected into the right flank of BALB/C-nude mice.
Result Emodin and its combination with Ara-C may be considered a promising therapeutic approach in AML and worthy of further investigation.
03. Reference
No. Title Href
1 Emodin and Its Combination with Cytarabine Induce Apoptosis in Resistant Acute Myeloid Leukemia Cells in Vitro and in Vivo. Cell Physiol Biochem. 2018;48(5):2061-2073. doi: 10.1159/000492544. Click
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